Information Section: Conditions
Condition:
Sleep Disorders
Source: Leslie E. Packer, PhD    
This File Last Updated: February 2009  

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RELATIONSHIP BETWEEN OTHER DISORDERS AND SLEEP PROBLEMS (CONT.)

Mood Disorders and Sleep Impairment

Depressed patients commonly complain of difficulties initiating sleep, maintaining sleep, and awakening early in the morning. . 

Bipolar Disorder has a significant association with sleep problems. Hypomania or mania can actually be induced in a significant subset of bipolar patients by using sleep deprivation. A number of studies have demonstrated that sleep disturbance is the most common precursor of mania.

But what happens to bipolar children and adults when they are in a normal (euthymic) mood state? Do they still have sleep disturbances? Harvey et al. (2005) compared euthymic bipolar patients to non-bipolar patients with insomnia, and subjects with good sleep. A combination of self-report and objective measures were used. They found that 70% of the euthymic bipolar patients (still) had a clinically significant sleep disturbance characterized by impaired sleep efficience, higher levels of anxiety and fear about poor sleep, lower daytime activity levels, and a tendency to misperceive sleep.

Staton (2008) provides a review of sleep problems in childhood-onset Bipolar Disorder in terms of subtypes of bipolar patterns as they relate to sleep onset and need for sleep. Whereas children and adolescents with part-day manic cycles and chronic mixed conditions typically exhibit delayed sleep onset, but not a decreased need for sleep, children with days-long manic cycles or chronic mania typically report decreased need for sleep.

Like Bipolar Disorder, depression is also associated with sleep issues. Some studies indicate that lack of sleep is associated with increased risk of suicidal ideation and increased risk of suicide attempts in the general population, independent of the impact of any comorbid disorders.

Tourette's Syndrome and Sleep Problems

Children and adolescents with Tourette's Syndrome (TS) report significantly more sleep problems than their non-TS peers. In boys with TS, sleep problems occur even more often when there is also comorbid Attention Deficit Hyperactivity Disorder. For children or teenagers with Tourette's, sleep onset may be delayed because they first have to "get their tics out."  They lie down to go to bed and may tic explosively or vigorously for an hour or more. 

Kostanecka-Endress et al. (2003) obtained objective measures of sleep on 17 unmedicated children and teens with TS who did not have comorbid ADHD and a control group. They found that children with TS demonstrated longer sleep period time, longer sleep latency, reduced sleep efficiency, and prolonged wakefulness after sleep onset. Their sleep profiles showed significantly more time awake and less sleep stage II. However, REM sleep variables, slow-wave sleep, and number of sleep stage changes were unaffected.

Obsessive-Compulsive Disorder and Sleep Problems 

Children and teenagers with anxiety disorders or Obsessive-Compulsive Disorder also experience sleep problems, but of a different kind. Students with OCD may stay up late into the night working to get a paper "perfect," or may be so anxious about a school assignment that they can't get a good night's sleep. Other children and adolescents with OCD may have time-consuming rituals that they must engage in at night that prevent them from getting to sleep at a reasonable hour: toys must be lined up "just so," there may be extensive and time-consuming hygiene rituals instead of just being able to take a quick shower and get to bed, the bedding must be in a particular way, or they may have extensive "good night" rituals involving a parent. These are just some examples. 

Storch, Murphy et al. (2008) assessed 66 children and adolescents with OCD were for OCD symptoms, depression symptoms, and anxiety symptoms. A subset of 41 children completed a trial of cognitive-behavior therapy. They found that 92% of the children experienced at least one sleep-related problem; 27.3% reported five or more types of sleep-related problems. The total number of sleep-related problems were positively correlated with OCD severity, anxiety severity, and parent ratings of internalizing problems. Significantly, some sleep-related problems decreased following cognitive-behavioral treatment.

Autism/Asperger's and Sleep Problems

Sleep problems have long been noted in autistic children, but the impression of the extent and nature of difficulties depends, in part, on what methodology the investigators use to study the problem. Of particular note for educators is a study by Elia et al. (2000), who found that some of the sleep measures were significantly correlated with the child's functioning. Nonverbal communication showed significant correlation with sleep period time, wakefulness after sleep onset, and total sleep time. Relating to people and activity level items were found to be significantly correlated with rapid eye movement density. 

In one of the larger studies using parental reports, Liu et al. (2007) studied 167 ASD children. They found that 86% of the children had at least one sleep problem almost every day. Problems included bedtime resistance (54%), insomnia (56%), parasomnias** (53%), sleep disordered breathing (25%), morning rise problems (45%), and daytime sleepiness (31%).

A study of 52 children with Asperger's Syndrome also found sleep-related problems (Paavonen, Vehkalahti, et al., 2008). They found that problems with sleep onset and maintenance, sleep-related fears, negative attitudes toward sleeping, and daytime somnolence were more frequent among children with AS than among controls. Short sleep duration was approximately twice as common in Asperger's as in the control group, while the risk for sleep onset problems was five times as likely. Almost 60% of the children and teens with Asperger's had a sleep-related problem.

LEARN MORE ABOUT IT

Adults with ADHD often suffer from RLS and PLMS. There is a national support organization for RLS where you can get more information on this disorder.

You can read a summary of a 1999 workshop online: Sleep Needs, Patterns and Difficulties of Adolescents: Summary of a Workshop Mary G. Graham, Editor; Forum on Adolescence, Board on Children, Youth, and Families, National Research Council, Institute of Medicine.

FOOTNOTES

* Permax® (pergolide) was withdrawn from the market in March 2007 at the request of the FDA due to concerns about heart valve damage.

**Parasomnias include nightmare disorder, sleep terror disorder, sleepwalking disorder, and parasomnias not otherwise specified.

Information Section: Conditions
Condition:
Sleep Disorders
Article: About Sleep Disorders
Source: Leslie E. Packer, PhD    
This File Last Updated: February 2009

Page 2 of 2

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